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A4262

Actinomycin D

Name: Actinomycin D
Brand: SIGMA

from Streptomyces sp., ≥95% (HPLC)

Sinônimo(s):

Actinomycin C₁, Actinomycin IV, Dactinomycin

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Sobre este item

Fórmula empírica (Notação de Hill):

C₆₂H₈₆N₁₂O₁₆

Número CAS:

50-76-0

Peso molecular:

1255.42

UNSPSC Code:

51282001

NACRES:

NA.76

PubChem Substance ID:

24890842

EC Number:

200-063-6

Beilstein/REAXYS Number:

605235

MDL number:

MFCD00005033

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Propriedades

biological source

Streptomyces sp.

Quality Level

200

assay

≥95% (HPLC)

form

powder

color

red, powder

mp

251-253

solubility

ethanol, DMSO: soluble

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

CC(C)[C@H]1NC(=O)[C@@H](NC(=O)c2ccc(C)c3OC4=C(C)C(=O)C(N)=C(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]6CCCN6C(=O)[C@H](NC5=O)C(C)C)C4=Nc23)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]7CCCN7C1=O

InChI

1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1

InChI key

RJURFGZVJUQBHK-IIXSONLDSA-N

Descrição

General description

Chemical structure: peptide

Application

Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation with wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells. Recommended for us in cell culture applications at 1μg/mL.

Biochem/physiol Actions

Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase.

Preparation Note

Actinomycin D is sold as red, shiny crystals and is soluble in acetonitrilie or acetone at 10 mg/mL and in DMSO at a minimum of 1 mg/mL. Some references also show slight solubility in water of 0.5 mg/mL.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Disclaimer

This product is hygroscopic and light-sensitive. If stored protected from light and moisture at 2-8°C, it remains unchanged, by HPLC testing, for at least 15 months. Unused dilute solutions of Actinomycin D are extremely sensitive to light and tend to adsorb to plastic and glass and should be discarded. However, frozen aliquots of concentrated stock solution are stable for at least a month.

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Este Item	SBR00013	A9415	A1410
Sigma-Aldrich A4262 Actinomycin D	Sigma-Aldrich SBR00013 Actinomycin D	Sigma-Aldrich A9415 Actinomycin D	Sigma-Aldrich A1410 Actinomycin D
mode of action DNA synthesis \| interferes	mode of action DNA synthesis \| interferes	mode of action DNA synthesis \| interferes	mode of action DNA synthesis \| interferes
antibiotic activity spectrum neoplastics	antibiotic activity spectrum neoplastics	antibiotic activity spectrum neoplastics	antibiotic activity spectrum neoplastics
Quality Level 200	Quality Level 200	Quality Level 300	Quality Level 300
form powder	form liquid, ready-to-use solution	form powder	form powder
assay ≥95% (HPLC)	assay -	assay ≥95%	assay ~98% (HPLC)
biological source Streptomyces sp.	biological source Streptomyces sp.	biological source Streptomyces sp.	biological source Streptomyces sp.

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300,H350,H360FD

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Repr. 1B

Classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Número de item de comércio global

SKU	GTIN
A4262-25MG	04061833268001
A4262-10MG	04061833267998
A4262-2MG	04061833268018
A4262-5MG	04061833268025

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