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Merck

O7389

Olprinone hydrochloride

≥98% (HPLC), solid

Sinônimo(s):

1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride, Loprinone hydrochloride

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Sobre este item

Fórmula empírica (Notação de Hill):
C14H10N4O · HCl
Número CAS:
119615-63-3
Peso molecular:
286.72
NACRES:
NA.77
PubChem Substance ID:
24724566
UNSPSC Code:
41106305
MDL number:
MFCD01749474
Assay:
≥98% (HPLC)
Form:
solid

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InChI

1S/C14H10N4O.ClH/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10;/h2-6,8H,1H3,(H,17,19);1H

SMILES string

Cl[H].CC1=C(C=C(C#N)C(=O)N1)c2ccc3nccn3c2

InChI key

PWTBMBAQRAOAFF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

beige

solubility

DMSO: ≤4 mg/mL, H2O: 6.8 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

Selective phosphodiesterase 3 (PDE3) inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe de armazenamento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
056K47151
056K4715

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Tiziana Genovese et al.
Neuroscience letters, 503(2), 93-99 (2011-08-30)
Olprinone hydrochloride, a specific phosphodiesterase III inhibitor, has anti-inflammatory effects in addition to its inotropic and vasodilatory effects. The purpose of this study was to examine the beneficial effects of olprinone on cerebral ischemia reperfusion injury. In the present study
Kenya Yamanaka et al.
The Journal of surgical research, 183(1), 391-396 (2012-12-19)
Donor safety is a major concern in living-donor liver transplantation. However, partial grafts do not meet the functional demands of recipients and lead to small-for-size syndrome (SFSS). In a previous study, we showed that olprinone (OLP), a selective phosphodiesterase ІІІ
Controlled reperfusion.
Hajime Ichikawa
General thoracic and cardiovascular surgery, 60(2), 65-67 (2012-02-14)
Emanuela Esposito et al.
PloS one, 5(9), e12170-e12170 (2010-09-11)
Olprinone hydrochloride is a newly developed compound that selectively inhibits PDE type III and is characterized by several properties, including positive inotropic effects, peripheral vasodilatory effects, and a bronchodilator effect. In clinical settings, olprinone is commonly used to treat congestive
Emanuela Mazzon et al.
Pharmacological research, 64(1), 68-79 (2011-01-05)
Olprinone is a specific phosphodiesterase (PDE)-III inhibitor, which has been found to have anti-inflammatory effects in addition to its main inotropic and peripheral vasodilatory effects. In the present study we investigated the effects of olprinone (0.2mg/kg, i.p.) on the development
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Phosphodiesterases

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and/or cGMP. There are 11 different mammalian PDE families.

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

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